The science behind our ingredients
Research Library
Functional mushrooms have been an integral part of traditional and holistic health for centuries. From Traditional Chinese Medicine (TCM) to modern mycotherapy. Today, even science increasingly confirms what old cultures have long known: functional mushrooms are full of bioactive substances with impressive potential.
We at smaints are convinced that transparency and facts are the basis for trust. That is why we have compiled a collection of scientific studies on the ingredients of our products for you. So you can discover for yourself what exciting effects the research describes.
Important note (Disclaimer): Due to legal regulations, we are unfortunately prohibited from making specific healing or effect promises for certain ingredients of our products. This is the reason why very little information can be found on the effect of some products. We have therefore taken all the more care to find studies on the ingredients of our products in order to confirm the effectiveness and create transparency. The studies are for information purposes only and are not a substitute for medical advice. In addition, you can do your own research and get your own picture of our products. We ask for your understanding.
Studies on Cordyceps
Energie und Vitalität
„Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human.”, Nagata et al. 2006; Lin & Li 2011
Sauerstoffversorgung (VO2 max)
„Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial.”, Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010)
Körperliche Leistung
„Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers”, Xiao Yi, Huang Xi-zhen & Zhu Jia-shi (2004).
Gedächtnis (Mausstudie)
„Improvement of Learning and Memory Induced by Cordyceps Polypeptide Treatment and the Underlying Mechanism.”, Yuan, G., An, L., Sun, Y., Xu, G., & Du, P. (2018).
Autoimmunerkrankungen der Schilddrüse
„Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases“. He, X. et al. 2016
Studies on Lions Mane
Kognitive Fähigkeiten
„Improvement of Cognitive Functions by Oral Intake of Hericium Erinaceus.", Saitsu, Y., A. Nishide, K. Kikushima, K. Shimizu, and K. Ohnuki.
Kognitive Fähigkeiten
„Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.”, K. Mori, S. Inatomi, K. Ouchi, Y. Azumi, T. Tuchida
Kognitive Fähigkeiten
„Effect of erinacine A-enriched Hericium erinaceus supplementation on cognition: A randomized, double-blind, placebo-controlled pilot study“, Maša Černelič Bizjak, Zala Jenko Pražnikar, Saša Kenig, Matjaž Hladnik, Dunja Bandelj, Andrej Gregori, Katja Kranjc (2024).
Nervenwachstum (Übersichtsarbeit)
“Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus.”,Bing-Ji Ma, Jin-Wen Shen, Hai-You Yu, Yuan Ruan, Ting-Ting Wu & Xu Zhao (2010)
Neuroprotektion (Übersichtsarbeit)
„Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential – A Narrative Review“, Alex Graça Contato & Carlos Adam Conte-Junior (2025).
Alzheimer (Pilotstudie)
„Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia: A Pilot Double-Blind Placebo-Controlled Study“, I-Chen Li, Han-Hsin Chang, Chuan-Han Lin, Wan-Ping Chen, Tsung-Han Lu, Li-Ya Lee, Yu-Wen Chen, Yen-Po Chen, Chin-Chu Chen & David Pei-Cheng Lin (2020).
Darmgesundheit & Immunmodulation
„Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota“. Diling, C. et al. (2017).
Studies on Chaga
Immunmodulation (Zellstudien)
„Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus.”, Won, D. P., Lee, J. S., Kwon, D. S., Lee, K. E., Shin, W. C., & Hong, E. K. (2011).
Darmflora (Mausstudie)
“Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice.”, Hu, Y., Teng, C., Yu, S., Wang, X., Liang, J., Bai, X., Dong, L., Song, T., Yu, M., & Qu, J. (2017).
Herpes-simplex-Virus (Zellstudie)
“Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.”, Pan, H. H., Yu, X. T., Li, T., Wu, H. L., Jiao, C. W., Cai, M. H., Li, X. M., Xie, Y. Z., Wang, Y., & Peng, T. (2013).
Hepatitis-Viren (Zellstudie)
„Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures.”, Shibnev, V. A., Mishin, D. V., Garaev, T. M., Finogenova, N. P., Botikov, A. G., & Deryabin, P. G. (2011).
Antioxidant (Zellstudie)
„Antioxidative properties of crude polysaccharides from Inonotus obliquus.”, Mu, H., Zhang, A., Zhang, W., Cui, G., Wang, S., & Duan, J. (2012).
Studies on Shiitake
Immunsystem (Übersicht von Tier und Humanstudien)
„The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies.” Shin, M. S., Park, H. J., Maeda, T., Nishioka, H., Fujii, H., & Kang, I. (2019).
Immunsystem, Entzündungen
„Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.”, Dai, X., Stanilka, J. M., Rowe, C. A., Esteves, E. A., Nieves, C., Jr, Spaiser, S. J., Christman, M. C., Langkamp-Henken, B., & Percival, S. S. (2015).
Antioxidant + Cholesterinwerte
„Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. “, Spim, S. R. V., Pistila, A. M. H., Pickler, T. B., Silva, M. T., & Grotto, D. (2021).
Studies on Agaricus blazei (Almond Mushroom)
Entzündungshemmend + Allergie (Übersicht präklinischer + klinischer Studien)
„Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes.”, Hetland, G., Tangen, J. M., Mahmood, F., Mirlashari, M. R., Nissen-Meyer, L. S. H., Nentwich, I., Therkelsen, S. P., Tjønnfjord, G. E., & Johnson, E. (2020).
Immunomodulation bei Autoimmunerkrankungen
“The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation.” Hetland, G. et al. 2011
Immunomodulation bei Autoimmunerkrankungen
“Antitumor, Anti-Inflammatory, and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms.” Hetland, G. et al., 2020
Birkenpollenallergie
„Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial.”, Mahmood, F., Hetland, G., Nentwich, I., Mirlashari, M. R., Ghiasvand, R., & Nissen-Meyer, L. S. H. (2019).
Studies on Maitake
Depression (Mausstudie)
„Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice.”, Bao, H., Ran, P., Sun, L., Hu, W., Li, H., Xiao, C., Zhu, K., & Du, J. (2017).
Blutfettwerte (Tierstudie)
„Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I.”, Kubo, K., & Nanba, H. (1997).
Diabetes (Tierstudie)
„Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats.”, Horio, H., & Ohtsuru, M. (2001).
Fruchtbarkeit, polyzystische Ovar-Syndrom
„Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate.”, Chen, J. T., Tominaga, K., Sato, Y., Anzai, H., & Matsuoka, R. (2010).
Studies on Reishi
Wohlbefinden
„Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia.”, Pazzi, F., Adsuar, J. C., Domínguez-Muñoz, F. J., García-Gordillo, M. A., Gusi, N., & Collado-Mateo, D. (2020).
Antioxidant
„Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers.”, Chiu, H. F., Fu, H. Y., Lu, Y. Y., Han, Y. C., Shen, Y. C., Venkatakrishnan, K., Golovinskaia, O., & Wang, C. K. (2017).
Blutzucker
„A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus.”, Yihuai Gao et al. 2004
Entzündungshemmung
“Anti-inflammatory Activities of Ganoderma lucidum (Lingzhi) and San-Miao-San Supplements in MRL/lpr Mice for the Treatment of Systemic Lupus Erythematosus” Cai, Zhe et al., 2016
